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I was diagnosed with PCOS about 15 years ago and after much trial and error with other medications, finally settled on Spironolactone as the best treatment for me. I have been on this medication at least 12 years. Initially I took 200mg/day but after about eight years it became less effective so my dosage was increased to 250mg/day which I'm still on. While I'm concerned about the risks of long-term usage of this drug, the benefits have been significant enough that I keep taking it. My worst symptom was the facial hair on my chin (looked like acne but was in fact infected hair follicles) that I plucked every night. Spironolactone reduced the amount of hair by about 50% but not more. Even after all these years I still have to pluck daily but its not as bad as it once was. The other benefits are that it controlled my excessive testosterone levels which in turn let to weight loss, not as much depression, and no more excruciatingly long and painful periods (in fact I only get a few periods a year now which is fine with me!). Ultrasound tests have shown my polycystic ovaries have less cysts than in the past before I started taking this drug. My doctor's plan is for me to continue on 250/mg day until menopause. However it is important to keep up with the latest research on this drug to make sure it is not causing any long-term damage. by MERLIN from Belgium, WI
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Shortly after my Dr. doubled my dosage from 5 mg to 10 mg, I developed leukopenia, which resulted in APL - a rate form of leukemia. This put me in the hospital for 4 weeks with a 50-50 chance of survival. I also had a brain bleed. I am currently on remission and feel that the Furosemide somehow caused the APL by ULYSSES from Armstrong, IA
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