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Duloxetine had been most effective at the beginning of treatment, feeling better after the first 48-72 hours. Happier thoughts, more outgoing and less anxiety in front of groups, more desire to be social. Some side effects are nausea even when taken with food in the morning, tiredness for about 1-2 hours after taking the medication. And the worst is weight gain even when maintaining a healthy moderate diet and exercise. I gained about 12 pounds in 6 weeks. Finally, feeling better and gradually off the drug with hopes of loosing the weight and staying healthy. I would recommend this drug in low dose for short term. by DERRICK from Ishpeming, MI
My feelings of hopelessness, depression and negativity during the week before my period diminished immediately (it's been over two cycles now). General depression symptoms were much slower to respond to the 20mg daily generic dose, and I didn't notice differences until about 5 weeks in. I will continue the dosage for sure. Only side effects are a bit of nervousness and some minor trouble falling asleep or staying asleep. by KIETH from Belfry, MT
It has stopped most of my pain in neck and upper back, but has not stopped pain in legs, especially knees. by BERNARD from Rosepine, LA
iam taking Endep hcl 500 mg for pre-hip surgey. have been taking for 4 days ,and i am itching. i have stop taking for 2 days,still am itching by JESS from Hemingford, NE
Very effective medication, however after taking prescribed dose I can feel decrease of hunger. I recommend blood testing during treatment! by THANH from Connellsville, PA
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